With the invention of printing, the great herbals arrived in the fifteenth and sixteenth centuries. In 1485 the Gart der Gesundheit appeared in Mainz. In 1542 Leonhart Fuchs published De historia stirpium, with beautiful woodcuts drawn from nature.
The Low Countries played a large role. The Mechelen physician Rembert Dodoens published his Cruydeboeck in Antwerp in 1554, one of the most important herbals of its time, which was translated into many languages. In England John Gerard’s Herball appeared in 1597, and in 1652 The English Physitian by Nicholas Culpeper, who made the knowledge accessible to ordinary people in English.
From the eighteenth century science grew out of herbalism. In 1785 William Withering described how foxglove helped with dropsy caused by heart failure. In the nineteenth century chemists isolated active substances from plants, such as morphine from the opium poppy in 1804. In 1897 Bayer made aspirin, based on a substance also found in willow bark and meadowsweet.